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Higher bone mineral density is associated with a decreased risk of colorectal adenomas
Author(s) -
Nock Nora L.,
PatrickMelin Aimee,
Cook Marc,
Thompson Cheryl,
Kirwan John P.,
Li Li
Publication year - 2010
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25722
Subject(s) - medicine , bone mineral , colorectal cancer , vitamin d and neurology , gastroenterology , colorectal adenoma , endocrinology , body mass index , colonoscopy , osteoporosis , cancer
Abstract Bone mineral density (BMD) is a biomarker for cumulative exposure to multiple factors including estrogen, calcium, vitamin D and physical activity, which have all been independently associated with colorectal cancer. Furthermore, higher levels of BMD have been inversely associated with colorectal cancer risk, particularly in postmenopausal women. However, no prior studies have examined the potential association between BMD and colorectal adenomas, which are precursor lesions to most colorectal cancers. Therefore, we evaluated the association between BMD, which was measured using a whole body, dual‐energy X‐ray absorptiometry scan and colorectal adenomas in 167 patients who underwent colonoscopy screening. We found that patients in the highest tertile of total body BMD (>1.294 g/cm 2 ) and in the middle tertile (≥1.167 to ≤1.294 g/cm 2 ) compared to those with a total body BMD in the lowest tertile (<1.167 g/cm 2 ) had a lower risk of colorectal adenomas (highest vs . lowest tertile: OR = 0.29 (0.10–0.84); middle vs . lowest tertile: OR = 0.26 (0.08–0.80); p ‐trend = 0.02). Stratification by gender revealed that this association was more pronounced in women (highest (>1.280 g/cm 2 ) vs . lowest (<1.130 g/cm 2 ) tertile: OR = 0.08 (0.01–0.70); middle (≥1.130 to ≤1.280 g/cm 2 ) vs . lowest tertile: OR = 0.15 (0.04–0.94); p ‐trend = 0.02) even after excluding hormone replacement therapy users (highest (>1.295 g/cm 2 ) and middle (≥1.132 to ≤1.295 g/cm 2 ) vs . lowest (<1.132 g/cm 2 ) tertile: OR = 0.17 (0.03–0.97); p ‐trend = 0.04). Our results show, for the first time, that BMD is inversely associated with colorectal adenomas, particularly in women. Although additional larger, prospective studies are needed, our results suggest that BMD may be a biomarker for colorectal cancer precursor lesions.