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Human glioblastoma‐initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection
Author(s) -
Kroonen Jérôme,
Nassen Jessica,
Boulanger YvesGautier,
Provenzano Fabian,
Capraro Valérie,
Bours Vincent,
Martin Didier,
Deprez Manuel,
Robe Pierre,
Rogister Bernard
Publication year - 2010
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25709
Subject(s) - subventricular zone , olfactory bulb , tropism , biology , glioblastoma , stem cell , pathology , cancer research , cancer stem cell , striatum , rostral migratory stream , neuroscience , neural stem cell , central nervous system , medicine , immunology , microbiology and biotechnology , dopamine , virus
In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described, and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate toward the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer‐initiating cells.