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Aging‐related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression
Author(s) -
Sprenger Cynthia C.,
Plymate Stephen R.,
Reed May J.
Publication year - 2010
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25615
Subject(s) - extracellular matrix , prostate cancer , cancer , tumor progression , tumor microenvironment , prostate , biology , extracellular , medicine , cancer research , pathology , microbiology and biotechnology
Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.