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IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high‐risk Chinese population
Author(s) -
Liu Li,
Xu Yan,
Liu Zheng,
Chen Jianguo,
Zhang Yixin,
Zhu Jian,
Liu Jibin,
Liu Sheng,
Ji Guozhong,
Shi Haibin,
Shen Hongbing,
Hu Zhibin
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25488
Subject(s) - hepatocellular carcinoma , odds ratio , medicine , gastroenterology , confidence interval , population , hbsag , oncology , hepatitis b virus , immunology , virus , environmental health
Abstract To investigate the association between the potentially functional polymorphisms in IL12A and IL12B , HBV infection and risk of hepatocellular carcinoma in a Chinese population, we genotyped three polymorphisms, rs568408 (3′UTR G>A), rs2243115 (5′UTR T>G) in IL12A and rs3212227 (3′UTR A>C) in IL12B in a case–control study of 869 hepatocellular carcinoma (HCC) cases and 891 cancer‐free controls. We found that the IL12A rs568408 GA/AA variant genotypes were associated with a significantly increased risk of HCC (adjusted odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.17–2.00), compared with the wild‐type GG homozygote. In the stratified analyses, the increased risk of HCC associated with rs568408 GA/AA was more evident in patients who were negative for HBsAg (adjusted OR = 1.71, 95% CI = 1.23–2.39). However, no significant associations between IL12A rs2243115 T/G, IL12B rs3212227 A/C and risk of HCC were observed. Our findings indicate that IL12A rs568408 may contribute to the risk of HCC and modify HCC risk associated with HBV infection.