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Allergy and glioma risk: Test of association by genotype
Author(s) -
Dobbins Sara E.,
Hosking Fay J.,
Shete Sanjay,
Armstrong Georgina,
Swerdlow Anthony,
Liu Yanhong,
Yu Robert,
Lau Ching,
Schoemaker Minouk J.,
Hepworth Sarah J.,
Muir Kenneth,
Bondy Melissa,
Houlston Richard S.
Publication year - 2011
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25483
Subject(s) - asthma , glioma , atopy , snp , etiology , epidemiology , causation , allergy , medicine , single nucleotide polymorphism , genetic association , genotype , oncology , immunology , genetics , biology , political science , gene , law
Although epidemiological studies have suggested an association between atopy and glioma risk, these observations have been based on self‐reporting of allergic conditions raising the possibility that associations may be noncausal and arise as a consequence of bias, reverse causation or other artifacts. Genetic information provides an alternative approach to investigate the relationship avoiding such biases. We analyzed 1,878 glioma cases and 3,670 controls for variants at 2q12, 5q12.1, 11q13 and 17q21 that are associated with asthma or eczema risk at p < 5.0 × 10 −7 . The SNP rs7216389, which tags the 3′ flanking region of ORMDL3 at 17q21 and has been associated with childhood asthma, was correlated with increased glioma risk (OR = 1.10; 95% CI: 1.01–1.19). These data provide evidence for a correlation between asthma susceptibility and glioma risk and illustrate the value of using genetics as an investigative tool for developing etiological hypotheses.