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Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)
Author(s) -
Jacobs Eric J.,
Chanock Stephen J.,
Fuchs Charles S.,
LaCroix Andrea,
McWilliams Robert R.,
Steplowski Emily,
StolzenbergSolomon Rachael Z.,
Arslan Alan A.,
BuenodeMesquita H. Bas,
Gross Myron,
Helzlsouer Kathy,
Petersen Gloria,
Zheng Wei,
Agalliu Ilir,
Allen Naomi E.,
Amundadottir Laufey,
BoutronRuault MarieChristine,
Buring Julie E.,
Canzian Federico,
Clipp Sandra,
Dorronsoro Miren,
Gaziano J. Michael,
Giovannucci Edward L.,
Hankinson Susan E.,
Hartge Patricia,
Hoover Robert N.,
Hunter David J.,
Jacobs Kevin B.,
Jenab Mazda,
Kraft Peter,
Kooperberg Charles,
Lynch Shan M.,
Sund Malin,
Mendelsohn Julie B.,
Mouw Tracy,
Newton Christina C.,
Overvad Kim,
Palli Domenico,
Peeters Petra H.M.,
Rajkovic Aleksandar,
Shu XiaoOu,
Thomas Gilles,
Tobias Geoffrey S.,
Trichopoulos Dimitrios,
Virtamo Jarmo,
WactawskiWende Jean,
Wolpin Brian M.,
Yu Kai,
ZeleniuchJacquotte Anne
Publication year - 2010
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25148
Subject(s) - medicine , pancreatic cancer , family history , odds ratio , breast cancer , oncology , cancer , colorectal cancer , ovarian cancer , prostate cancer , cohort , gynecology
A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers ( i.e ., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case‐control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case‐control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate‐adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19–2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12–1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52–1.31), breast cancer (OR = 1.21, 95% CI = 0.97–1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93–1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.