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Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia
Author(s) -
Termini Lara,
Maciag Paulo Cesar,
Soares Fernando Augusto,
ogaki Suely,
Pereira Sônia Maria Miranda,
Alves Venâncio Avancini Ferreira,
LongattoFilho Adhemar,
Villa Luisa Lina
Publication year - 2010
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.25046
Subject(s) - cervicitis , cervical intraepithelial neoplasia , immunohistochemistry , pathology , kallikrein , biomarker , cervical cancer , carcinogenesis , medicine , staining , intraepithelial neoplasia , biology , cancer , enzyme , gynecology , prostate cancer , biochemistry
Overexpression of kallikrein 7, a proteolytic enzyme important for epithelial cell shedding, may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion. In this study, we have evaluated hK7 (human kallikrein 7) protein levels by immunohistochemistry in 367 cervical histological samples including 35 cases of cervicitis, 31 low‐grade cervical intraepithelial neoplasia, 51 high‐grade cervical intraepithelial neoplasia (H‐SIL), 197 squamous cervical carcinomas (SCC) and 53 cervical adenocarcinomas. We have observed that hK7 staining increased with the severity of cervical disease. Intense hK7 staining was found in 15.2% of cervicitis samples, in contrast to 55% of H‐SIL and 68% of SCC. Moreover, 92.5% of adenocarcinomas also exhibited intense hK7 staining. Differences in the expression of hK7 could potentially be used as a biomarker for the characterization of different stages of cervical disease.