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Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition
Author(s) -
Lahmann Petra H.,
Cust Anne E.,
Friedenreich Christine M.,
Schulz Mandy,
Lukanova Annekatrin,
Kaaks Rudolf,
Lundin Eva,
Tjønneland Anne,
Halkjær Jytte,
Severinsen Marianne Tang,
Overvad Kim,
Fournier Agnès,
ChabbertBuffet Nathalie,
ClavelChapelon Françoise,
Dossus Laure,
Pischon Tobias,
Boeing Heiner,
Trichopoulou Antonia,
Lagiou Pagona,
Naska Androniki,
Palli Domenico,
Grioni Sara,
Mattiello Amalia,
Tumino Rosario,
Sacerdote Carlotta,
Redondo MaríaLuisa,
Jakszyn Paula,
Sánchez MaríaJosé,
Tormo MaríaJosé,
Ardanaz Eva,
Arriola Larraitz,
Manjer Jonas,
Jirström Karin,
BuenodeMesquita H. Bas,
May Anne M.,
Peeters Petra H.M.,
OnlandMoret N. Charlotte,
Bingham Sheila,
Khaw KayTee,
Allen Naomi E.,
Spencer Elizabeth,
Rinaldi Sabina,
Slimani Nadia,
Chajes Véronique,
Michaud Dominique,
Norat Teresa,
Riboli Elio
Publication year - 2009
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24952
Subject(s) - medicine , european prospective investigation into cancer and nutrition , prospective cohort study , body mass index , hazard ratio , waist , risk factor , anthropometry , cancer , waist–hip ratio , gynecology , obesity , confounding , proportional hazards model , confidence interval , obstetrics , oncology
Abstract We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant, epithelial ovarian cancer diagnosed during a mean 8.9 years of follow‐up. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. Compared to women with body mass index (BMI) < 25 kg/m 2 , obesity (BMI ≥ 30 kg/m 2 ) was associated with excess ovarian cancer risk for all women combined (HR = 1.33, 95% CI = 1.05–1.68; p trend = 0.02) and postmenopausal women (HR = 1.59, 95% CI = 1.20–2.10; p trend = 0.001), but the association was weaker for premenopausal women (HR = 1.16, 95% CI = 0.65–2.06; p trend = 0.65). Neither height or weight gain, nor BMI‐adjusted measures of fat distribution assessed by waist circumference, waist–hip ratio (WHR) or hip circumference were associated with overall risk. WHR was related to increased risk of mucinous tumors (BMI‐adjusted HR per 0.05 unit increment = 1.17, 95% CI = 1.00–1.38). For all women combined, no other significant associations with risk were observed for specific histological subtypes. This large, prospective study provides evidence that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women.