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Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese
Author(s) -
Matsuo Keitaro,
Tajima Kazuo,
Suzuki Takeshi,
Kawase Takakazu,
Watanabe Miki,
Shitara Kohei,
Misawa Kazunari,
Ito Seiji,
Sawaki Akira,
Muro Kei,
Nakamura Tsuneya,
Yamao Kenji,
Yamamura Yoshitaka,
Hamajima Nobuyuki,
Hiraki Akio,
Tanaka Hideo
Publication year - 2009
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24519
Subject(s) - odds ratio , helicobacter pylori , stomach cancer , stomach , medicine , allele , cancer , oncology , case control study , biology , gastroenterology , genetics , gene
A recent whole‐genome association study identified a strong association between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case‐control study, we aimed to validate this association, and further to explore environmental factors possibly interacting with PSCA polymorphisms in 708 incident stomach cancer cases and 708 age–sex matched controls. The association between PSCA polymorphisms and Helicobacter pylori infection was also examined. We found that rs2294008 and rs2976392, which were strongly linked to each other ( D ′ = 1.00), were significantly associated with stomach cancer risk. Per allele odds ratio for rs2994008 was 1.40 (95% confidence interval: 1.19–1.65; p = 3.7 × 10 −5 ). We found significant interaction with a family history of stomach cancer in first‐degree relatives ( p ‐heterogeneity = 0.009). Similar to originally reported association, we found significant heterogeneity between diffuse and intestinal type ( p ‐heterogeneity = 0.007). No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation. © 2009 UICC