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Dietary fat intake and risk of skin cancer: A prospective study in Australian adults
Author(s) -
Ibiebele Torukiri I.,
van der Pols Jolieke C.,
Hughes Maria Celia,
Marks Geoffrey C.,
Green Adèle C.
Publication year - 2009
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24481
Subject(s) - medicine , basal cell carcinoma , skin cancer , prospective cohort study , poisson regression , polyunsaturated fatty acid , saturated fat , cancer , basal cell , physiology , fatty acid , population , biology , environmental health , biochemistry , cholesterol
Although intakes of dietary fat have been associated with both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin, the evidence is sparse and inconsistent. This study prospectively investigated the association between total dietary fat; saturated, polyunsaturated and monounsaturated fatty acids; and percent energy from fat in relation to BCC and SCC of the skin. At baseline in 1992, total fat intake and intake of fatty acids were assessed in an Australian community‐based longitudinal study, using a validated semi‐quantitative food frequency questionnaire in 1,057 adult residents (aged 25–75 years) in Nambour, Queensland. Information on demography, sun‐sensitivity history and sun exposure factors were obtained using self‐administered questionnaires. Associations with BCC and SCC in terms of persons newly affected and of tumor counts were assessed using Poisson and negative binomial regression models, respectively, based on incident, histologically‐confirmed tumors occurring between 1992 and 2002. No significant linear trends were observed in overall risk of BCC or SCC of the skin with increasing total fat intake. However, in participants with a history of skin cancer, total fat intake (multivariable adjusted RR = 2.42, 95% CI = 1.20–4.88; p for trend = 0.01) was associated with increased numbers of SCC tumors comparing the highest to lowest tertile. In conclusion, SCC tumor risk increased as total fat intake increased in people with a history of skin cancer. Dietary fats were not associated with BCC occurrence. © 2009 UICC