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Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer
Author(s) -
Ieta Keisuke,
Tanaka Fumiaki,
Yokobori Takehiko,
Kita Yoshiaki,
Haraguchi Naotsugu,
Mimori Koshi,
Kato Hiroyuki,
Asao Takayuki,
Inoue Hiroshi,
Kuwano Hiroyuki,
Mori Masaki
Publication year - 2009
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24453
Subject(s) - colorectal cancer , laser capture microdissection , microdissection , cancer research , metastasis , medicine , cancer , lymphovascular invasion , oncology , real time polymerase chain reaction , gene expression , biology , clinical significance , pathology , gene , biochemistry
Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 ( STC2 ) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real‐time quantitative reverse transcription‐polymerase chain reaction. A number of genes upregulated in colorectal cancer cells compared to normal colorectal epithelial cells were identified including STC2 . STC2 gene expression in cancer tissue was higher than in corresponding normal colorectal epithelial tissue in 124 of 139 cases (89.2%, p < 0.01). Tumors with high STC2 expression showed higher frequencies of lymph node metastasis, lymphatic invasion, tumor depth, tumor size and AJCC Stage classification ( p < 0.01). Patients with high STC2 expression also showed significantly worse overall survival rates than those with low STC2 expression ( p < 0.01). Furthermore, STC2 gene appeared to be associated with colorectal cancer progression and may be a useful prognostic indicator for colorectal cancer. © 2009 UICC