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A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
Author(s) -
Allen Naomi E.,
Roddam Andrew W.,
Sieri Sabina,
Boeing Heiner,
Jakobsen Marianne Uhre,
Overvad Kim,
Tjønneland Anne,
Halkjær Jytte,
Vineis Paolo,
Contiero Paolo,
Palli Domenico,
Tumino Rosario,
Mattiello Amalia,
Kaaks Rudolf,
Rohrmann Sabine,
Trichopoulou Antonia,
Zilis Demosthenes,
Koumantaki Yvoni,
Peeters Petra H.,
BuenodeMesquita H. Bas,
Barricarte Aurelio,
Rodríguez Laudina,
Dorronsoro Miren,
Sánchez MariaJosé,
Chirlaque María Dolores,
Esquius Laura,
Manjer Jonas,
Wallström Peter,
Ljungberg Börje,
Hallmans Göran,
Bingham Sheila,
Khaw KayTee,
Boffetta Paolo,
Norat Teresa,
Mouw Traci,
Riboli Elio
Publication year - 2009
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24447
Subject(s) - medicine , prospective cohort study , renal cell carcinoma , european prospective investigation into cancer and nutrition , cancer , kidney cancer , hazard ratio , physiology , body mass index , proportional hazards model , cohort study , carcinoma , risk factor , oncology , endocrinology , confidence interval
Abstract Previous case‐control studies have suggested that a high intake of animal foods and its associated nutrients are associated with an increased risk of renal cell carcinoma, although data from prospective studies are limited. We report here on the relationship between macronutrient intake and renal cell carcinoma incidence among 435,293 participants enrolled in the European Prospective Investigation into Cancer and Nutrition. Cox proportional hazard models were used to examine the association of dietary intake of fat, protein, carbohydrate, fiber and cholesterol and risk of renal cell carcinoma adjusted for age, sex, center, height, body mass index, physical activity, education, smoking, menopausal status, alcohol and energy intake. During an average 8.8 years of follow‐up, 507 renal cell carcinoma cases occurred. Risk of renal cell carcinoma was not associated with macronutrient intake, including nutrients derived from animal sources. Our results indicate that macronutrient intake is not associated with risk of renal cell carcinoma in this cohort of European men and women. © 2009 UICC