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Immunoglobulin subclass levels in patients with non‐Hodgkin lymphoma
Author(s) -
Biggar Robert J.,
Christiansen Michael,
Rostgaard Klaus,
Smedby Karin Ekström,
Adami HansOlov,
Glimelius Bengt,
Hjalgrim Henrik,
Melbye Mads
Publication year - 2009
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24245
Subject(s) - subclass , immunoglobulin e , immunoglobulin d , immunology , antibody , lymphoma , b cell , medicine , chronic lymphocytic leukemia , atopy , allergy , leukemia
Allergy/atopy has been suggested to protect against non‐Hodgkin lymphoma (NHL) and specific IgE levels are decreased in patients with NHL. We speculated that all immunoglobulin subclass levels might be downregulated in NHL and examined levels of IgM, IgD, IgA, IgE, IgG and IgG 4 in 200 NHL patients and 200 age‐ and sex‐matched controls. Patients with B‐cell NHL of many types had consistently lower median immunoglobulin subclass levels than controls. In every subclass except IgD, about 10–15% of B‐cell NHL patients had absolute levels below the 2.5 percentile of controls. Subclass levels correlated with each other and many patients had more than one significantly low level. Levels were lowest for IgG 4 and IgE. Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma had especially low total IgE levels. In other B‐cell NHL types, total IgE levels were decreased to a similar extent as other immunoglobulin subclasses. In conclusion, low IgE levels are only part of a more generalized loss of immunoglobulins of all subtypes in a wide variety of B‐cell NHL types. Low immunoglobulin levels appear to be a consequence of B‐cell NHL presence, and we speculate about molecular mechanisms that could reduce all immunoglobulin subclasses in B‐cell NHL. © 2008 Wiley‐Liss, Inc.