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Evaluation of thoracic tumors with 18 F‐FMT and 18 F‐FDG PET‐CT: A clinicopathological study
Author(s) -
Kaira Kyoichi,
Oriuchi Noboru,
Shimizu Kimihiro,
Ishikita Tomohiro,
Higuchi Tetsuya,
Imai Hisao,
Yanagitani Noriko,
Sunaga Noriaki,
Hisada Takeshi,
Ishizuka Tamotsu,
Kanai Yoshikatsu,
Endou Hitoshi,
Nakajima Takashi,
Endo Keigo,
Mori Masatomo
Publication year - 2008
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.24034
Subject(s) - medicine , positron emission tomography , angiogenesis , nuclear medicine , cd31 , lung cancer , metastasis , immunohistochemistry , cd34 , pathology , radiology , cancer , biology , stem cell , genetics
L‐[3‐ 18 F]‐α‐methyltyrosine ( 18 F‐FMT) is an aminoacid tracer for positron emission tomography (PET). The aim of this study was to determine whether PET‐CT with 18 F‐FMT provides additional information for the preoperative diagnostic workup as compared with 18 F‐FDG PET. PET‐CT studies with 18 F‐FMT and 18 F‐FDG were performed as a part of the preoperative workup in 36 patients with histologically confirmed bronchial carcinoma, 6 patients with benign lesions and a patient with atypical carcinoid. Expression of L‐type amino acid transporter 1 (LAT1), CD98, Ki‐67 labeling index, VEGF, CD31 and CD34 of the resected tumors were analyzed by immunohistochemical staining, and correlated with the uptake of PET tracers. For the detection of pulmonary malignant tumors, 18 F‐FMT PET exhibited a sensitivity of 84% whereas the sensitivity for 18 F‐FDG PET was 89% ( p = 0.736). 18 F‐FMT PET‐CT and 18 F‐FDG PET‐CT agreed with pathological staging in 85 and 68%, respectively ( p = 0.151). 18 F‐FMT uptake was closely correlated with LAT1, CD98, cell proliferation and angiogenesis. The specificity of 18 F‐FMT PET for diagnosing thoracic tumors was higher than that of 18 F‐FDG PET. Our results suggest that coexpression of LAT1 and CD98 in addition to cell proliferation and angiogenesis is relavant for the progression and metastasis of lung cancer. © 2008 Wiley‐Liss, Inc.