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Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease
Author(s) -
PerezAndres Martin,
Almeida Julia,
MartinAyuso Marta,
De Las Heras Natalia,
Moro Maria Jesus,
MartinNuñez Guillermo,
Galende Josefina,
Cuello Rebeca,
Abuín Isabel,
Moreno Inmaculada,
Domínguez Mercedes,
Hernandez Jose,
Mateo Gema,
San Miguel Jesus F.,
Orfao Alberto
Publication year - 2008
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23941
Subject(s) - beta 2 microglobulin , cd19 , antigen , cell adhesion molecule , cd38 , monoclonal gammopathy of undetermined significance , immunology , multiple myeloma , bone marrow , human leukocyte antigen , cd80 , cd40 , monoclonal , medicine , biology , antibody , monoclonal antibody , in vitro , microbiology and biotechnology , cytotoxic t cell , stem cell , biochemistry , cd34
Abstract Clonal plasma cells (PC) from different types of monoclonal gammopathies (MG) display distinct phenotypes consistent with an increased antigen‐presentation and T‐cell costimulation in MG of undetermined significance that deteriorates in malignant conditions. Expression of other cell surface and soluble molecules ( e.g . adhesion/proliferation molecules) involved in the interaction between clonal PC and the bone marrow (BM) microenvironment has also been related to malignant PC, although the exact clinical significance of their expression remains largely unknown. Analysis of cell surface levels of several of these molecules in multiple myeloma (MM) patients shows an association between lower expression on BMPC of the HLA‐I and β2‐microglobulin antigen‐presenting molecules, the CD126 and CD130 IL6 receptor (IL6R) chains, and CD38, and adverse prognostic features of the disease. Likewise, patients showing higher soluble levels of antigen‐presenting molecules (HLA‐I and β2‐microglobulin), IL6R and CD95 tended to be associated with more aggressive disease behavior. In contrast, CD40, CD86, CD56, CD19, and CD45 were not associated with patients' outcome. Interestingly, upon considering the ratio between the soluble and PC membrane expression of each molecule, an increased adverse prognostic impact was observed for both HLA‐I and β2‐microglobulin, but not for the other molecules. Multivariate analysis confirmed the independent prognostic value of cell surface expression of CD126 on BMPC together with serum β2‐microglobulin and LDH. In summary, our results show an abnormal distribution of the cellular and soluble compartments of the HLA‐I, IL6R, and to a lower extent, CD95 molecules, in MM, associated with the clinical characteristics and behavior of the disease. © 2008 Wiley‐Liss, Inc.