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Prenatal and perinatal risk factors for neuroblastoma
Author(s) -
Bluhm Elizabeth,
McNeil Dawn Elizabeth,
Cnattingius Sven,
Gridley Gloria,
El Ghormli Laure,
Fraumeni Joseph F.
Publication year - 2008
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23847
Subject(s) - medicine , odds ratio , respiratory distress , neuroblastoma , obstetrics , pediatrics , pregnancy , confidence interval , apgar score , case control study , fetus , surgery , biology , genetics , cell culture
Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case–control design, we investigated prenatal, perinatal and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed in the year 1973–1995 with the Swedish Medical Birth Register. Five living controls per case were randomly selected from the birth registry, matched by gender and age. Increased risks were associated with maternal anemia during pregnancy (odds ratio (OR) = 2.95, 95% confidence interval (CI): 1.53, 5.69), neonatal respiratory distress (OR = 3.61, 95% CI: 1.41, 9.24) and low (below or equal to 7) 1‐min Apgar score (OR = 2.23, 95% CI: 1.41, 3.52). Increased risks were limited to cases diagnosed before 1 year of age. Markers of prenatal, perinatal and neonatal distress may be associated with neuroblastoma in infancy, but not with diagnoses at 1 year or above. Published 2008 Wiley‐Liss, Inc.