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A polygenic model with common variants may predict lung adenocarcinoma risk in humans
Author(s) -
Galvan Antonella,
Falvella Felicia S.,
Spinola Monica,
Frullanti Elisa,
Leoni Vera P.,
Noci Sara,
Alonso Maria R.,
Zolin Anna,
Spada Elena,
Milani Silvano,
Pastorino Ugo,
Incarbone Matteo,
Santambrogio Luigi,
Neira Anna Gonzalez,
Dragani Tommaso A.
Publication year - 2008
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23789
Subject(s) - single nucleotide polymorphism , odds ratio , genome wide association study , snp , lung cancer , biology , allele , genetics , case control study , population , polygenic risk score , lung cancer susceptibility , oncology , genotype , medicine , gene , environmental health
Genome‐wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single‐nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case–control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6–0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population. © 2008 Wiley‐Liss, Inc.