Premium
Birth‐related characteristics, congenital malformation, maternal reproductive history and neuroblastoma: The ESCALE study (SFCE )
Author(s) -
Munzer Caroline,
Menegaux Florence,
Lacour Brigitte,
ValteauCouanet Dominique,
Michon Jean,
Coze Carole,
Bergeron Christophe,
Auvrig Anne,
Bernard Frédéric,
Thomas Caroline,
Vannier JeanPierre,
Kanold Justyna,
Rubie Hervé,
Hémon Denis,
Clavel Jacqueline
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23301
Subject(s) - odds ratio , medicine , neuroblastoma , confidence interval , etiology , pregnancy , pediatrics , family history , population , obstetrics , case control study , gynecology , surgery , biology , genetics , environmental health , cell culture
Since neuroblastoma occurs very early in children's lives, it has been hypothesized that pre‐ and perinatal factors may play a role in its etiology. This study investigated the role of birth characteristics, congenital malformation and maternal reproductive history in neuroblastoma. The data used were generated by the national population‐based case–control study, ESCALE, conducted in France in 2003–2004. The mothers of 191 neuroblastoma cases and 1,681 controls, frequency‐matched by age and gender, were interviewed by telephone, using a standardized questionnaire, on several factors including pregnancy, medical history, lifestyle, childhood medical conditions and exposures. A positive association between congenital malformation and all neuroblastoma cases was observed [Odds ratio (OR) = 2.2, 95% confidence interval (95% CI): 1.1–4.5]. Congenital malformations were highly associated to neuroblastoma in children aged less than 1 year (OR = 16.8, 95% CI: 3.1–90), while no association was observed in children aged 1 year or more (OR = 1.0, 95% CI: 0.3–2.9). A negative association with a maternal history of spontaneous abortions was also found (OR = 0.6, 95% CI: 0.4–0.9). The results strongly support the hypothesis that congenital anomalies may be associated with neuroblastoma, particularly in infant (less than 1 year of age). © 2007 Wiley‐Liss, Inc.