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The expression of low molecular weight protein tyrosine phosphatase is up‐regulated in 1,2‐dimethylhydrazine‐induced colon tumours in rats
Author(s) -
Marzocchini Riccardo,
Malentacchi Francesca,
Biagini Massimiliano,
Cirelli Domenico,
Luceri Cristina,
Caderni Giovanna,
Raugei Giovanni
Publication year - 2008
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23266
Subject(s) - carcinogenesis , malignancy , protein tyrosine phosphatase , colorectal cancer , 1,2 dimethylhydrazine , cancer research , biology , pathology , cancer , tyrosine , medicine , azoxymethane , biochemistry
Recent studies have assessed the role of low molecular weight protein tyrosine phosphatase (LMW‐PTP) in cell transformation and tumour onset and progression, observing a significant increase in the expression of LMW‐PTP mRNA and protein in human breast, colon, bladder and kidney tumour samples. Moreover, its enhanced expression is generally prognostic of a more aggressive cancer. To better understand the role of this protein during colon carcinogenesis and to study whether its overexpression is also observed in earlier phases of carcinogenesis, we studied its expression in colon tumours, induced in rats by treatment with 1,2‐dimethylhydrazine (DMH), an animal model that resemble the sequential formation of histopathological lesions of spontaneous carcinogenesis in humans. The results show a significant increase in LMW‐PTP expression in adenocarcinomas, suggesting that this phenomenon is associated with the onset of malignancy. Moreover a significant overexpression of LMW‐PTP transcript is associated with tumours originating in the proximal (right) part of the colon, confirming an observation already reported for human colon cancer. © 2007 Wiley‐Liss, Inc.