Premium
Impact of serum total cholesterol on the incidence of gastric cancer in a population‐based prospective study: The Hisayama study
Author(s) -
Asano Kouichi,
Kubo Michiaki,
Yonemoto Koji,
Doi Yasufumi,
Ninomiya Toshiharu,
Tanizaki Yumihiro,
Arima Hisatomi,
Shirota Tomoko,
Matsumoto Takayuki,
Iida Mitsuo,
Kiyohara Yutaka
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23191
Subject(s) - medicine , cancer , gastroenterology , prospective cohort study , hazard ratio , incidence (geometry) , population , confidence interval , confounding , body mass index , physics , environmental health , optics
The results of prospective studies that have examined the association between serum cholesterol levels and the incidence of gastric cancer remain controversial. To examine this issue in a general population, a total of 2,604 subjects aged 40 years or older were followed up prospectively for 14 years. During the follow‐up period, gastric cancer developed in 97 subjects. The age‐ and sex‐adjusted incidence of gastric cancer by quartiles of serum cholesterol level, namely, <4.06, 4.06–5.32, 5.33–6.04 and ≥6.05 mmol/L, were 3.9, 3.3, 3.1 and 2.1 per 1,000 person–years, respectively. The risk of gastric cancer increased with decreasing cholesterol level (age‐ and sex‐adjusted hazard ratio [HR], 1.22; 95% confidence interval [CI], 1.01–1.49; p = 0.04 for a decrease of 1 mmol/L in serum cholesterol level). This inverse association remained unchanged even after adjustment for other confounding factors, namely, Helicobacter pylori infection, atrophic gastritis, family history of malignant neoplasm, smoking habits, body mass index, hemoglobin A1c, white blood cell count and dietary factors (adjusted HR, 1.28; 95% CI, 1.03–1.58; p = 0.02). This association was significant for intestinal‐type gastric cancers, but not for diffuse‐type. As regards cancer stage, the inverse cholesterol‐cancer association was marginally significant for early gastric cancer after multivariate‐adjustment (adjusted HR, 1.25; 95% CI, 0.97–1.61; p = 0.09), but was not for advanced gastric cancer probably due to the small number of cases. In conclusion, our findings suggest that low serum cholesterol levels are an independent risk factor for developing gastric cancer, especially intestinal‐type gastric cancer. © 2007 Wiley‐Liss, Inc.