Premium
Inflammation and cancer: An ancient link with novel potentials
Author(s) -
Perwez Hussain S.,
Harris Curtis C.
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23173
Subject(s) - inflammation , epigenetics , cancer , microrna , biology , dna methylation , suppressor , immunology , innate immune system , immunity , carcinogenesis , gene , cancer research , immune system , genetics , gene expression
Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g. , cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post‐translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. © 2007 Wiley‐Liss, Inc.