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Cutaneous human papillomavirus 88: Remarkable differences in viral load
Author(s) -
Kullander Johanna,
Handisurya Alessandra,
Forslund Ola,
Geusau Alexandra,
Kirnbauer Reinhard,
Dillner Joakim
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.23115
Subject(s) - actinic keratoses , viral load , pathology , human papillomavirus , basal cell , basal (medicine) , biology , cell , virology , viral disease , virus , medicine , genetics , insulin , endocrinology
Abstract A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma . The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79 actinic keratoses, 73 seborrhoeic keratoses, 169 basal cell carcinomas and 126 SCCs) and 362 healthy skin biopsies found detectable HPV88 DNA in only 7 specimens. All these had very low viral loads (<1 copy/10 3 cells) implying extreme biological variability in viral load. © 2007 Wiley‐Liss, Inc.