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Risk of human T‐lymphotropic virus type I‐associated diseases in Jamaica with common HLA types
Author(s) -
Goedert James J.,
Li HongChuan,
Gao XiaoJiang,
Chatterjee Nilanjan,
Sonoda Shunro,
Biggar Robert J.,
Cranston Beverley,
Kim Norma,
Carrington Mary,
Morgan Owen,
Hanchard Barrie,
Hisada Michie
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22767
Subject(s) - tropical spastic paraparesis , asymptomatic , immunology , human leukocyte antigen , medicine , odds ratio , asymptomatic carrier , haplotype , population , allele , virology , biology , antigen , myelopathy , genetics , environmental health , psychiatry , gene , spinal cord
Human T‐lymphotropic virus‐I (HTLV‐I) causes adult T‐cell leukemia/lymphoma (ATL) and HTLV‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class‐I (A,B) and class‐II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population‐based, asymptomatic HTLV‐I‐infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV‐I proviral load between asymptomatic carriers with common versus uncommon types was compared by t ‐test. ATL differed from asymptomatic carriers in overall DQB1 allele and class‐I haplotype frequencies ( p ≤≤ 0.04). ATL risk was increased significantly with common HLA‐B (OR 2.25, 95% CI 1.19–4.25) and DRB1 (OR 2.11, 95% CI 1.13–3.40) alleles. Higher prevalence HLA‐B alleles were associated with higher ATL risk (OR 1.14 per quartile, p trend = 0.02). Asymptomatic carriers with common HLA‐B alleles had marginally higher HTLV‐I proviral load ( p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA‐B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma. © 2007 Wiley‐Liss, Inc.