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Dietary patterns and risk of laryngeal cancer: An exploratory factor analysis in Uruguayan men
Author(s) -
De Stefani Eduardo,
Boffetta Paolo,
Ronco Alvaro L.,
DeneoPellegrini Hugo,
Acosta Giselle,
Mendilaharsu María
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22765
Subject(s) - malignancy , medicine , etiology , risk factor , cancer , carcinoma , gastroenterology , oncology , carcinogenesis
Laryngeal carcinoma is a common malignancy among Uruguayan men. A number of case–control and prospective studies have studied the role of diet in this malignancy. To our knowledge, this is the first study that has explored broad dietary patterns by factor (principal components) analysis. The results of this study retained 6 dietary patterns. Pattern 5 ( drinker ) was directly associated with risk of laryngeal carcinoma (OR 3.8, 95% CI 1.9–7.5), whereas the Pattern 2 ( healthy ) was protective (OR 0.6, 95% CI 0.3–1.2). Finally, the Pattern 6 ( western ) displayed a significant increase in risk of 3.2 (95% CI 1.6–6.2). Most dietary patterns were associated with supraglottic cancer, supporting a possible etiological difference between supraglottic and glottic carcinomas. This study also suggests that the analysis of dietary patterns might be a useful approach for investigating nutritional factors implicated in laryngeal carcinogenesis. © 2007 Wiley‐Liss, Inc.