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Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45
Author(s) -
Chen Zigui,
Fu Leiping,
Herrero Rolando,
Schiffman Mark,
Burk Robert D.
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22632
Subject(s) - open reading frame , virology , biology , cervical cancer , human papillomavirus , cancer , medicine , genetics , gene , peptide sequence
Abstract Human papillomavirus (HPV) type 97 was identified and the genome was cloned from cervicovaginal cells of a Costa Rican woman with a normal Pap smear. The HPV97 L1 open reading frame (ORF) was most closely related to HPV45 (84% identity) and HPV18 (79% identity), placing it into the high‐risk α7 species. Ectopic expression of the HPV97 E6 and E7 proteins significantly decreased steady state p53 and pRb levels using an in vitro cotransfection assay, respectively. These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations. © 2007 Wiley‐Liss, Inc.