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Coffee and tea consumption and risk of hepatocellular carcinoma in Italy
Author(s) -
Montella Maurizio,
Polesel Jerry,
La Vecchia Carlo,
Maso Luigino Dal,
Crispo Anna,
Crovatto Marina,
Casarin Pietro,
Izzo Francesco,
Tommasi Luigi Gabriele,
Talamini Renato,
Franceschi Silvia
Publication year - 2007
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22509
Subject(s) - hepatocellular carcinoma , medicine , odds ratio , confounding , logistic regression , confidence interval , case control study , consumption (sociology) , environmental health , surgery , demography , sociology , social science
The role of coffee in the aetiology of hepatocellular carcinoma has raised great interest. In Italy, coffee consumption is high, thus allowing the investigation of the topic over a broad range of consumption. A hospital‐based case‐control study was conducted in Italy in 1999–2002, including 185 incidents, histologically confirmed cases of hepatocellular carcinoma aged 43–84 years. Controls were 412 subjects admitted to the same hospitals' networks for acute, non‐neoplastic diseases unrelated to diet. Coffee and tea consumption were assessed using a validated food‐frequency questionnaire. Odds ratios (ORs) and corresponding the 95% confidence intervals (CI) were computed using unconditional multiple logistic regression, adjusting for hepatitis viruses seropositivity, alcohol intake, smoking habits and other potential confounding factors. Compared to people who drunk <14 cups/week of coffee, the risk of hepatocellular carcinoma decreased for increasing levels of consumption (OR = 0.4, 95% CI: 0.2–1.1 for ≥28 cups/week, p for trend = 0.02). In the present study, inverse relations were observed across strata of hepatitis C and, B virus infections and alcohol drinking. No significant association emerged with consumption of decaffeinated coffee (OR = 0.7, 95% CI = 0.2–2.5) or tea (OR = 1.4, 95% CI = 0.8–2.7). The present study supports the hypothesis of a favourable effect of coffee, though not decaffeinated coffee and tea, on the risk on hepatocellular carcinoma. © 2006 Wiley‐Liss, Inc.