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Association of interleukin‐1 gene polymorphisms with gastric cancer: A meta‐analysis
Author(s) -
Wang Ping,
Xia Harry HuaXiang,
Zhang JianYing,
Dai LiPing,
Xu XueQin,
Wang KaiJuan
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22353
Subject(s) - odds ratio , medicine , cancer , confidence interval , genotype , gastroenterology , oncology , case control study , meta analysis , gene , genetics , biology
Previous studies on the association between interleukin‐1 ( IL‐1 ) genetic polymorphisms and the risk of gastric cancer have produced conflicting results. The purpose of this study was to examine the association between IL‐1 genotype and gastric caner by systematically reviewing the risk of the original studies. Thirty‐nine studies, which included 6,863 gastric cancer cases and 8,434 controls, met the inclusion criteria and were included in the meta‐analysis. By pooling all the studies identified, the summary odds ratio (OR) of gastric cancer risk associated with IL‐1B –511T, −31C, +3954T and IL‐1RN *2 was 1.26 (95% confidence interval (CI): 1.03–1.55), 1.00 (95% CI: 0.82–1.22), 1.37 (95% CI: 0.94–2.00) and 1.20 (95% CI: 1.01–1.41), respectively. A stratified analysis showed that IL‐1B –511T was associated with an increased risk of gastric cancer (intestinal type) (OR = 1.76, 95% CI: 1.12–2.57). Moreover, IL‐1RN *2 was also associated with an increased risk of gastric cancer among Caucasians (OR = 1.30, 95% CI: 1.09–1.54). In conclusion, IL‐1B –511 and IL‐1RN genetic polymorphisms are associated with an increased risk of developing gastric cancer. © 2006 Wiley‐Liss, Inc.