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Increased risk of gastrointestinal lymphoma in carriers of the 657del5 NBS1 gene mutation
Author(s) -
Steffen Jan,
Maneva Galina,
Popławska Lidia,
Varon Raymonda,
Mioduszewska Olga,
Sperling Karl
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22280
Subject(s) - nijmegen breakage syndrome , lymphoma , mutation , germline mutation , incidence (geometry) , medicine , proband , population , heterozygote advantage , gastroenterology , allele , genetics , biology , gene , dna damage , dna , physics , environmental health , optics , ataxia telangiectasia
The NBS1 gene mutation, 657del5, frequent in the Slavic populations of Central Europe, is found in most patients with Nijmegen breakage syndrome (NBS), a recessive autosomal disorder with a very high incidence of non‐Hodgkin lymphoma (NHL). We have previously described 2 heterozygous 657del5 mutation carriers among 42 adult NHL probands from Central Poland. Here we report 6 additional carriers of the 657del5 mutation and 2 carriers of the pathogenic NBS1 R215W mutation, among 186 other NHL patients also from Central Poland. The 657del5 carrier frequency in the pooled group of these 228 patients was significantly higher than in population controls (OR 5.85, 95% CI: 2.29–15.00, p = 0.0001). Interestingly, 4 of these carriers were found among 37 patients with gastrointestinal lymphoma (OR 19.52, 95% CI: 5.82–65.42, p = 0.0002). These findings imply that heterozygous NBS1 germline mutations may contribute significantly to the overall incidence of NHL, especially of the gastrointestinal tract, in Central Europe. © 2006 Wiley‐Liss, Inc.