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HLA‐class II haplotype associations with ovarian cancer
Author(s) -
Kübler Kirsten,
Arndt Peter F.,
Wardelmann Eva,
Krebs Dieter,
Kuhn Walther,
van der Ven Katrin
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22266
Subject(s) - haplotype , human leukocyte antigen , allele , ovarian cancer , biology , immunology , carcinogenesis , cancer , ovarian carcinoma , pathogenesis , genetics , antigen , gene
The development of cancer is a multistep process that is characterized by the accumulation of genetic alterations in cells and changed cellular interactions with the surrounding healthy tissues. The human immune system is believed to be intrinsically involved in this process. The correlation of certain human leukocyte antigen (HLA)‐class I and II haplotypes with tumorigenesis is documented in a variety of tumors. However, few data exist on the possible association of specific HLA‐class II alleles or haplotypes with ovarian cancer. In our sample of 52 Caucasian patients with primary ovarian carcinoma and 239 female healthy local controls, we observed a significantly increased incidence of the HLA‐class II haplotypes DRB1*0301 – DQA1*0501 – DQB1*0201 ( p < 0.001) and DRB1*1001 – DQA1*0101 – DQB1*0501 ( p < 0.001) in the patients. Our data suggest that HLA‐class II loci or individual HLA‐class II haplotypes may be involved in the pathogenesis of ovarian cancer. © 2006 Wiley‐Liss, Inc.