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Circulating enterolactone and risk of endometrial cancer
Author(s) -
ZeleniuchJacquotte Anne,
Lundin Eva,
Micheli Andrea,
Koenig Karen L.,
Lenner Per,
Muti Paola,
Shore Roy E.,
Johansson Ingegerd,
Krogh Vittorio,
Lukanova Annekatrin,
Stattin Pär,
Afanasyeva Yelena,
Rinaldi Sabina,
Arslan Alan A.,
Kaaks Rudolf,
Berrino Franco,
Hallmans Göran,
Toniolo Paolo,
Adlercreutz Herman
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22140
Subject(s) - enterolactone , phytoestrogens , medicine , endometrial cancer , prospective cohort study , body mass index , odds ratio , cancer , endocrinology , physiology , gynecology , sex hormone binding globulin , oncology , hormone , estrogen , androgen
It has been suggested that phytoestrogens protect against hormone‐dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case–control study nested within 3 prospective cohort studies, in New York, Sweden and Italy. Serum or plasma samples had been collected at enrollment and stored at −80°C. A total of 153 cases, diagnosed a median of 5.3 years after blood donation, and 271 matched controls were included. No difference in circulating enterolactone was observed between cases (median, 19.2 nmol/L) and controls (18.5 nmol/L). Adjusting for body mass index, the odds ratio for the top tertile of enterolactone, as compared to the lowest was 1.2 (95% CI, 0.7–2.0; p for trend = 0.53). Lack of association was observed in both pre‐ and postmenopausal women. No correlation was observed between enterolactone and circulating estrogens or SHBG in healthy postmenopausal women. These results do not support a protective role of circulating lignans, in the range of levels observed, against endometrial cancer. © 2006 Wiley‐Liss, Inc.