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Coffee consumption and stomach cancer risk in a cohort of Swedish women
Author(s) -
Larsson Susanna C.,
Giovannucci Edward,
Wolk Alicja
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22105
Subject(s) - stomach cancer , prospective cohort study , hazard ratio , medicine , stomach , cancer , cohort study , cohort , population , proportional hazards model , demography , confidence interval , environmental health , sociology
Few prospective studies have examined the relationship between coffee consumption and risk of stomach cancer, and the findings have been inconsistent. We prospectively investigated the association of long‐term coffee consumption with risk of stomach cancer in a population‐based cohort study of 61,433 Swedish women. Information on coffee consumption was collected with a food‐frequency questionnaire at baseline (1987–1990) and updated in 1997. During a mean follow‐up of 15.7 years from 1987 through June 2005, 160 incident cases of stomach cancer were diagnosed. Coffee consumption was positively associated with the risk of stomach cancer. Compared to women who consumed 1 or fewer cups of coffee per day, the multivariate hazard ratios were 1.49 (95% = 0.97–2.27) for women who drank 2–3 cups per day and 1.86 (95% CI = 1.07–3.25) for those who drank 4 or more cups per day ( p for trend = 0.01). An increase of 1 cup of coffee per day was associated with a statistically significant 22% increased risk of stomach cancer (hazard ratio = 1.22; 95% CI = 1.05–1.42). These prospective data suggest that coffee consumption may increase the risk of stomach cancer in a dose–response manner. This finding needs to be confirmed in other prospective studies. © 2006 Wiley‐Liss, Inc.