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Association of vitamin D receptor Fok I polymorphism with prostate cancer risk, clinicopathological features and recurrence of prostate specific antigen after radical prostatectomy
Author(s) -
Huang ShuPin,
Huang ChaoYuan,
Wu WenJeng,
Pu YeongShiau,
Chen Jun,
Chen YunYun,
Yu ChiaCheng,
Wu Tony T.,
Wang JyhSeng,
Lee YingHuei,
Huang JongKhing,
Huang ChunHsiung,
Wu MingTsang
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22053
Subject(s) - prostate cancer , calcitriol receptor , medicine , prostatectomy , prostate specific antigen , prostate , oncology , vitamin d and neurology , genotype , population , cancer , gastroenterology , urology , endocrinology , biology , genetics , environmental health , gene
To investigate the effect of vitamin D receptor (VDR) Fok I polymorphism on susceptibility to prostate cancer and the outcome of the disease in a Taiwanese population, we genotyped a total of 416 prostate cancer patients, 502 age‐matched male controls and 189 non age‐matched symptomatic benign prostatic hyperplasia. Although we did not find a significant association between VDR Fok I genotypes and overall prostate cancer risk, we found that in men aged less than or equal to the median age of 73 years with VDR Fok I F allele specifically had an increased risk of prostate cancer with a marginal significant trend (OR, 2.08; 95% CI, 1.00–4.34, p for trend = 0.056). The FF genotype was also highly associated with more aggressive prostate cancer (Gleason score 8–10) (OR, 2.47; 95% CI, 1.20–5.08) than did the Ff and ff genotypes. After adjusting other covariates, we found that in patients who had localized prostate cancer for which a radical prostatectomy was performed ( n = 131), the VDR Fok I FF genotype was associated with worse prostate‐specific antigen (PSA) recurrence‐free survival (hazard ratio = 3.25, 95% CI = 1.32–8.00, p = 0.010). Our findings suggest that the VDR FF genotype may increase the risk of early‐onset prostate cancer and is associated with more aggressive disease. Furthermore, the VDR polymorphism could be used as a prognostic marker for localized prostate cancer after radical prostatectomy. © 2006 Wiley‐Liss, Inc.