Premium
Structure and function of the components of the human DNA mismatch repair system
Author(s) -
Jascur Thomas,
Boland C. Richard
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22023
Subject(s) - dna mismatch repair , dna repair , dna , genetics , biology , carcinogenesis , germline mutation , germline , mutation , lynch syndrome , cancer , gene , cancer research , computational biology
DNA mismatch repair (MMR) is one of the several enzyme systems involved in DNA homeostasis. DNA MMR is involved in the repair of specific types of errors that occur during new DNA synthesis; loss of this system leads to an accelerated accumulation of potential mutations, and predisposes to certain types of cancers. Germline mutations in some of the DNA MMR genes cause the hereditary cancer predisposition, Lynch syndrome. This review addresses advances in the biochemistry of DNA MMR and its relationship to carcinogenesis. © 2006 Wiley‐Liss, Inc.