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Breast cancer risk in relation to abortion: Results from the EPIC study
Author(s) -
Reeves Gillian K.,
Kan SauWan,
Key Tim,
Tjønneland Anne,
Olsen Anja,
Overvad Kim,
Peeters Petra H.,
ClavelChapelon Françoise,
Paoletti Xavier,
Berrino Franco,
Krogh Vittorio,
Palli Domenico,
Tumino Rosario,
Panico Salvatore,
Vineis Paulo,
Gonzalez Carlos A.,
Ardanaz Eva,
Martinez Carmen,
Amiano Pilar,
Quiros José R.,
Tormo Maria R.,
Khaw KayTee,
Trichopoulou Antonia,
Psaltopoulou Theodora,
Kalapothaki Victoria,
Nagel Gabriele,
ChangClaude Jenny,
Boeing Heiner,
Lahmann Petra H.,
Wirfält Elisabet,
Kaaks Rudolf,
Riboli Elio
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.22001
Subject(s) - abortion , medicine , obstetrics , breast cancer , gynecology , relative risk , cancer , pregnancy , confidence interval , genetics , biology
The role of spontaneous and induced abortion on breast cancer risk is examined among 267,361 women recruited into the European Prospective Investigation into Cancer and nutrition between 1992 and 2000. The data were collected from 20 centers, across 9 countries, and included information on a total of 4,805 women with breast cancer, of whom 1,657 reported having ever had any type of abortion. Overall, the relative risk of breast cancer in women who reported ever having had a spontaneous abortion was not significantly elevated when compared with women who reported never having had such an abortion (RR = 1.07, 95% CI = 0.99–1.14). However, there was some evidence of a slight increase in the risk of breast cancer among women who reported having had 2 or more spontaneous abortions (1.20, 1.07–1.35). The relative risk of breast cancer among women who reported ever having had an induced abortion when compared to women who reported never having had an induced abortion was 0.95 (0.87–1.03). Overall, the findings provide further unbiased evidence of the lack of an adverse effect of induced abortion on breast cancer risk. © 2006 Wiley‐Liss, Inc.