Premium
On the proposed association of the ATM variants 5557G>A and IVS38‐8T>C and bilateral breast cancer
Author(s) -
Langholz Bryan,
Bernstein Jonine L.,
Bernstein Leslie,
Olsen Jørgen H.,
BørresenDale AnneLise,
Rosenstein Barry S.,
Gatti Richard A.,
Concan Patrick
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.21876
Subject(s) - breast cancer , medicine , oncology , population , cancer , haplotype , epidemiology , allele , gynecology , genetics , biology , gene , environmental health
reported that a haplotype composed of the alleles 5557G>A andIVS38-8T>C was statistically signicantly associated with bilat-eral breast cancer. They observed 5 haplotype carriers among 16(31.3%) bilateral breast cancer patients studied when comparedto 7 carriers among 160 (4.4%) unilateral breast cancer patients(OR 5 9.9). The observed frequency of the haplotype in a sampleof cancer-free female blood donors from the same geographicalarea did not differ statistically from that observed among unilat-eral cases (4.2% vs. 4.4%, respectively). These ndings led Heik-kinen et al.