On the proposed association of the ATM variants 5557G>A and IVS38‐8T>C and bilateral breast cancer | Zendy

Langholz Bryan | Zendy; Bernstein Jonine L. | Zendy; Bernstein Leslie | Zendy; Olsen Jørgen H. | Zendy; BørresenDale AnneLise | Zendy; Rosenstein Barry S. | Zendy; Gatti Richard A. | Zendy; Concan Patrick | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

On the proposed association of the ATM variants 5557G>A and IVS38‐8T>C and bilateral breast cancer

Author(s) -

Langholz Bryan,

Bernstein Jonine L.,

Bernstein Leslie,

Olsen Jørgen H.,

BørresenDale AnneLise,

Rosenstein Barry S.,

Gatti Richard A.,

Concan Patrick

Publication year - 2006

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.21876

Subject(s) - breast cancer , medicine , oncology , population , cancer , haplotype , epidemiology , allele , gynecology , genetics , biology , gene , environmental health

reported that a haplotype composed of the alleles 5557G>A andIVS38-8T>C was statistically signicantly associated with bilat-eral breast cancer. They observed 5 haplotype carriers among 16(31.3%) bilateral breast cancer patients studied when comparedto 7 carriers among 160 (4.4%) unilateral breast cancer patients(OR 5 9.9). The observed frequency of the haplotype in a sampleof cancer-free female blood donors from the same geographicalarea did not differ statistically from that observed among unilat-eral cases (4.2% vs. 4.4%, respectively). These ndings led Heik-kinen et al.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research