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CDKN2A common variant and multi‐organ cancer risk—a population‐based study
Author(s) -
Dębniak Tadeusz,
Scott Rodney J.,
Huzarski Tomasz,
Byrski Tomasz,
Rozmiarek Andrzej,
Dębniak Boguslaw,
Górski Bohdan,
Cybulski Cezary,
Mędrek Krzysztof,
Mierzejewski Marek,
Masojc Bartłomiej,
Matyjasik Joanna,
Złowocka Elzbieta,
Teodorczyk Urszula,
Lener Marcin,
KlujszoGrabowska Ewa,
NejWołosiak Katarzyna,
Jaworowska Ewa,
Oszutowska Dorota,
Szymańska Anna,
Szymańska Jolanta,
Castaneda Jennifer,
van de Wetering Thierry,
Suchy Janina,
Kurzawski Grzegorz,
Oszurek Oleg,
Narod Steven,
Lubinski Jan
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.21760
Subject(s) - cdkn2a , cancer , colorectal cancer , medicine , population , lung cancer , oncology , environmental health
The population frequencies of the CDKN2A common variants remain undetermined. In Poland, there is a common variant of the CDKN2A: an alanine to threonine substitution (A148T), which has been detected in other populations. We have recently showed that it is significantly overrepresented among Polish melanoma patients when compared to general population. Herein, we ascertained the prevalence of the A148T variant in 3,583 unselected cancer cases and 3,000 random control subjects from the same Polish population. We evaluated eleven different malignancies, representing the majority of all common cancer sites. Positive association with A148T variant was observed for lung cancer (OR, 2.0; p = 0.0052). A similar trend, although nonsignificant after the Bonferroni correction, was observed for colorectal cancer (OR, 1.5; p = 0.5499). These results suggest that A148T variant may be associated with a multi‐organ cancer risk in the Polish population. © 2006 Wiley‐Liss, Inc.