Premium
Association between diabetes mellitus and pre‐malignant oral diseases: A cross sectional study in Kerala, India
Author(s) -
Dikshit Rajesh P.,
Ramadas K.,
Hashibe Mia,
Thomas Gigi,
Somanathan Thara,
Sankaranarayanan R.
Publication year - 2006
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.21345
Subject(s) - medicine , diabetes mellitus , odds ratio , oral submucous fibrosis , leukoplakia , confidence interval , cancer , cross sectional study , dermatology , gastroenterology , pathology , endocrinology
Recent studies have suggested role of diabetes mellitus in the development of periodontal diseases, oral inflammatory and neoplastic lesions. We analysed data from randomised oral cancer screening trial in Kerala, India, to study the association between chronic diseases in general, diabetes mellitus in particular, and pre‐malignant oral lesions and conditions. A total of 927 subjects with oral leukoplakia, 170 with oral submucous fibrosis, 100 with erythroplakia lesions and 47,773 apparently healthy subjects constituted the cases and controls respectively for our present study. The odds ratio (OR) for oral leukoplakia among women with a history of diabetes mellitus was found to be 2.0 (95% confidence interval (CI) = 1.4–2.9) whereas that for erythroplakia was 3.2 (95% CI = 1.3–7.9), after adjusting for potential confounders. No statistically significant association between diabetes mellitus and oral submucous fibrosis and pre‐cancerous lesions/conditions in men was found. An association between diabetes mellitus and pre‐malignant oral lesions among women has been observed in our study, although the underlying mechanisms are not clear. This needs to be further evaluated in other settings. © 2005 Wiley‐Liss, Inc.