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Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers
Author(s) -
Nkondjock André,
Ghadirian Parviz,
Kotsopoulos Joanne,
Lubinski Jan,
Lynch Henry,
KimSing Charmaine,
Horsman Douglas,
Rosen Barry,
Isaacs Claudine,
Weber Barbara,
Foulkes William,
Ainsworth Peter,
Tung Nadine,
Eisen Andrea,
Friedman Eitan,
Eng Charis,
Sun Ping,
Narod Steven A.
Publication year - 2005
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.21296
Subject(s) - medicine , breast cancer , odds ratio , confidence interval , brca mutation , logistic regression , confounding , oncology , demography , cancer , case control study , consumption (sociology) , gynecology , social science , sociology
Although there are several plausible biologic mechanisms whereby coffee consumption might influence the risk of breast cancer, epidemiologic evidence is limited. We assessed the association between coffee consumption and breast cancer risk among high‐risk women who carry BRCA mutations. We performed a matched case‐control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries. Average lifetime coffee consumption was estimated via a self‐administered questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. After adjustment for potential confounders, the ORs for breast cancer in BRCA carriers who habitually drank 0, 1–3, 4–5 and 6 or more cups of coffee were 1.00, 0.90 (95% CI 0.72–1.12), 0.75 (95% CI 0.47–1.19) and 0.31 (95% CI 0.13–0.71; p ‐trend = 0.02). The effect was limited to the consumption of caffeinated coffee. These results suggest that among women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of consumption may in fact be related to reduced breast cancer risk. © 2005 Wiley‐Liss, Inc.