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Case‐control study of familial lung cancer risks in UK women
Author(s) -
Matakidou Athena,
Eisen Tim,
Bridle Helen,
O'Brien Mary,
Mutch Rosalind,
Houlston Richard S.
Publication year - 2005
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.21012
Subject(s) - lung cancer , medicine , odds ratio , family history , family aggregation , confidence interval , cancer , first degree relatives , case control study , disease , logistic regression , risk factor , relative risk , respiratory disease , lung
Family history data from a case‐control study of lung cancer conducted in the United Kingdom between 1999 and 2004 were analysed to estimate familial risks of the disease. Comparison of lung cancer prevalence in first‐degree relatives of 1,482 female lung cancer cases and 1,079 female controls was undertaken using logistic regression adjusting for age and tobacco exposure. Overall, lung cancer in a first‐degree relative was associated with a significant increase in the risk of lung cancer [odds ratio (OR) 1.49; 95% confidence interval (CI), 1.13–1.96]. For cases with early onset of the disease (< 60 years), the OR of lung cancer was 2.02 (95% CI, 1.22–3.34). Having 2 or more affected relatives was associated with an OR of 2.68 (95% CI, 1.29–5.55), with a significant trend in risk according to the number of relatives affected ( p = 0.001). An increased risk of lung cancer associated with family history of the disease was observed when analysis was restricted to lifetime nonsmokers, although this did not reach significance (OR 1.23; 95% CI, 0.65–2.31). Results confirm previous findings and support the role of a familial predisposition to lung cancer. © 2005 Wiley‐Liss, Inc.