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Hepatitis C infection is not associated with systemic HIV‐associated non‐hodgkin's lymphoma: A cohort study
Author(s) -
Waters Laura,
Stebbing Justin,
Mandalia Sundhiya,
Young Anne Marie,
Nelson Mark,
Gazzard Brian,
Bower Mark
Publication year - 2005
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20988
Subject(s) - medicine , lymphoma , immunosuppression , incidence (geometry) , non hodgkin's lymphoma , hepatitis c virus , immunology , hepatitis c , population , cohort , virus , physics , environmental health , optics
Abstract Immunosuppression induced by the human immunodeficiency virus (HIV) increases the risk of developing non‐Hodgkin's lymphoma (NHL). As the hepatitis C virus (HCV) has been implicated in the development of B cell lymphomas, we compared the incidence of systemic NHL during HIV infection compared to HIV and HCV co‐infection. Of 5,832 individuals studied during the era of highly active anti‐retroviral therapy (HAART), 102 patients were diagnosed with systemic NHL. The incidence of systemic NHL was 6.9 of 10 4 patient years during HIV infection compared to 7.1 of 10 4 patient years during HIV alone ( p = 0.9). In this immunocompromised patient population, there was no association between HCV infection and an increased risk of lymphoma. © 2005 Wiley‐Liss, Inc.