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SPOC1, a novel PHD‐finger protein: Association with residual disease and survival in ovarian cancer
Author(s) -
Mohrmann Gerrit,
Hengstler Jan G.,
Hofmann Thomas G.,
Endele Sabine U.,
Lee Brendan,
Stelzer Christiane,
Zabel Bernhard,
Brieger Juergen,
Hasenclever Dirk,
Tanner Berno,
Sagemueller Jens,
Sehouli Jalid,
Will Hans,
Winterpacht Andreas
Publication year - 2005
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20912
Subject(s) - ovarian cancer , cancer research , cancer , biology , gene expression , messenger rna , stage (stratigraphy) , oncology , survival analysis , gene , in situ hybridization , disease , medicine , pathology , genetics , paleontology
We report the identification of a novel human gene ( SPOC1 ) which encodes a protein with a PHD‐finger domain. The gene is located in chromosomal region 1p36.23, a region implicated in tumor development and progression. RNA in situ hybridization experiments showed strong SPOC1 expression in some rapidly proliferating cell types, such as spermatogonia, but not in nonpro‐liferating mature spermatocytes. In addition, high SPOC1 mRNA expression was observed in several ovarian cancer cell lines. This prompted us to systematically examine SPOC1 expression in ovarian cancer in relation to prognosis. SPOC1 mRNA expression was quantified in tumor tissue of 103 patients with epithelial ovarian cancer. Interestingly, SPOC1 was associated with residual disease, whereby patients with unresectable tumors showed higher levels compared to patients without residual tumor tissue after surgery ( p = 0.029). The univariable proportional hazards model showed an association between SPOC1 expression and survival ( p = 0.043, relative risk = 1.535). Median survival time was 1,596 days for patients with low SPOC1 expression vs. only 347 days for patients with high expression, using Kaplan‐Meier analysis. However, SPOC1 was not associated with survival when multivariable analysis was adjusted for residual disease. This can be explained by the correlation between residual disease and SPOC1 expression. In conclusion, SPOC1 is a novel PHD‐finger protein showing strong expression in spermatogonia and ovarian cancer cells. SPOC1 overexpression was associated with unresectable carcinomas and shorter survival in ovarian cancer. © 2005 Wiley‐Liss, Inc.

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