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Parathyroid adenoma and primary CNS tumors
Author(s) -
Bäcklund L. Magnus,
Grandér Dan,
Brandt Lena,
Hall Per,
Ekbom Anders
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20743
Subject(s) - adenoma , primary hyperparathyroidism , medicine , primary (astronomy) , parathyroid adenoma , pathology , parathyroid neoplasm , physics , astronomy
Hyperparathyroidism onset at a young age is one feature in multiple endocrine neoplasia (MEN) type 1 and MEN type 2A cancer syndromes. There are several case reports of MEN Type 1‐associated central nervous system (CNS) tumors. To determine if there is an association between parathyroid adenomas and CNS tumors, we used Swedish registry data to identify all individuals operated on for parathyroid adenomas between 1958–99 ( n = 12,468). Follow‐up for the occurrence of CNS tumors in these individuals was through linkage with the Swedish Cancer Registry. There were 70 observed cases of a CNS tumor diagnosed after a parathyroid adenoma, to be compared to 35 expected (standard incidence ratio [SIR] = 2.0; 95% confidence interval [CI] = 1.5–2.5). This increased risk was independent of duration of follow‐up and was confined to meningiomas (SIR = 2.4, 95% CI = 1.7–3.4) and neurinomas (SIR = 3.4, 95% CI = 1.5–6.8). These results strongly indicate an association between these tumor forms that may be genetic, environmental (such as radiation) or a combination of both. © 2004 Wiley‐Liss, Inc.