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Recent advances in tumour antigen‐specific therapy: In vivo veritas
Author(s) -
Mahnke Yolanda D.,
Speiser Daniel,
Luescher Immanuel F.,
Cerottini JeanCharles,
Romero Pedro
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20572
Subject(s) - in vivo , antigen , immunotherapy , adoptive cell transfer , cancer , ex vivo , cancer immunotherapy , immunology , medicine , cancer research , clinical trial , biology , immune system , pathology , t cell , microbiology and biotechnology
Modern cancer therapies should strive not only to eliminate malignant tissues but also to preserve healthy tissues and the patient's quality of life. Antigen‐specific immunotherapy approaches are promising for either aspect since they are designed to only act against tissues expressing 1 or more specified tumour antigens. In order to develop successful vaccine and adoptive transfer protocols, longitudinal monitoring of cancer patients taking part in clinical trials is mandatory. Here, in vivo expansion of antigen‐specific cells, as well as their ex vivo functional status represent important parameters to be analysed. To obtain results that most closely reflect the cells' in vivo status, functional assays must be carried out with as little in vitro culturing as possible. The present minireview discusses recent advances in these domains.