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Mutant BRCA1 alleles transmission: Different approaches and different biases
Author(s) -
de la Hoya Miguel,
MeijersHeijboer Hanne,
Fernández Juan Manuel,
Díez Orland,
Osorio Ana,
Alonso Carmen,
van Leeuwen Inge,
DíazRubio Eduardo,
Cornelisse Cees,
Benítez Javier,
Devilee Peter,
Caldés Trinidad
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20541
Subject(s) - allele , mutant , identification (biology) , genetics , transmission (telecommunications) , biology , computational biology , evolutionary biology , computer science , gene , telecommunications , ecology
Recently, a non‐random transmission of BRCA1 mutant alleles to the off‐spring of carriers has been suggested. If confirmed by further studies, the finding will have important implications both for risk assessment and the understanding of BRCA1 biology. However, these kind of analysis are not easy to perform due to several ascertainment biases inherent to the identification of BRCA1 carriers. In this report we propose different approaches to overcome such biases and we present additional data supporting a non‐random transmission of BRCA1 mutant alleles.