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Alcohol consumption and risk of prostate cancer in middle‐aged men
Author(s) -
Schoonen W. Marieke,
Salinas Claudia A.,
Kiemeney Lambertus A.L.M.,
Stanford Janet L.
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20528
Subject(s) - prostate cancer , medicine , odds ratio , random digit dialing , relative risk , risk factor , logistic regression , population , prostate , cancer , case control study , confidence interval , demography , environmental health , sociology
Alcohol consumption is a modifiable lifestyle factor that may affect prostate cancer risk. Alcohol alters the hormonal milieu and contains chemical substances such as flavonoids (red wine), which may alter tumor cell growth. Data from a population‐based case‐control study in King County, WA, were utilized to evaluate the association of alcohol consumption with prostate cancer in middle‐aged men. A total of 753 newly diagnosed prostate cancer cases, 40–64 years of age, participated in the study. Seven hundred three control subjects, frequency matched to cases by age, were selected through random digit dialing. All participants completed an in‐person interview on lifetime alcohol consumption and other risk factors for prostate cancer. Logistic regression models were used to estimate odds ratios (OR) and assess significance (95% confidence intervals [CI]). All tests of statistical significance were two‐sided. No clear association with prostate cancer risk was seen for overall alcohol consumption. Each additional glass of red wine consumed per week showed a statistically significant 6% decrease in relative risk (OR = 0.94; 95% CI = 0.90–0.98), and there was evidence for a decline in risk estimates across increasing categories of red wine intake (trend p = 0.02). No clear associations were seen for consumption of beer or liquor. Our present study suggests that consumption of beer or liquor is not associated with prostate cancer. There may be, however, a reduced relative risk associated with increasing level of red wine consumption. Further research is needed to evaluate the potential negative association between red wine intake and prostate cancer risk.