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Downregulation of KiSS‐1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma
Author(s) -
Dhar Dipok Kumar,
Naora Hiroyuki,
Kubota Hirofumi,
Maruyama Riruke,
Yoshimura Hiroshi,
Tonomoto Yasuhito,
Tachibana Mitsuo,
Ono Takashi,
Otani Hiroki,
Nagasue Naofumi
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20357
Subject(s) - kiss (tnc) , cancer , medicine , metastasis , tumor progression , downregulation and upregulation , cancer research , oncology , pathology , biology , gene , computer network , biochemistry , computer science
KiSS‐1 is a promising candidate tumor‐suppressor gene and may play a key role in the metastatic cascade. The expression profile and the role of KiSS‐1 in cancer progression are largely unknown in most of the cancers, including gastric cancer. In this study, KiSS‐1 expression was evaluated by RNase protection assay and localization was done by in situ hybridization in 40 gastric cancers and their adjacent normal gastric mucosa. For comparison with clinicopathologic characteristics and patient prognosis, all patients were divided into 2 groups having high and low KiSS‐1 expression by using the median as the cutoff value of KiSS‐1 expression as determined by the RNase protection assay. Gastric cancers with low KiSS‐1 had frequent venous invasion, distant metastasis and tumor recurrence. Accordingly, patients with low KiSS‐1 ‐expressing tumors had a significantly worse overall and disease‐free survival. In multivariate analysis, KiSS‐1 became the strongest independent prognostic factor among the conventional prognosticators for gastric cancer patients. Collectively, these findings suggest that KiSS‐1 may play a crucial role in gastric cancer invasion and could be a useful target for therapeutic intervention. © 2004 Wiley‐Liss, Inc.