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Expression in bladder transitional cell carcinoma by real‐time quantitative reverse transcription polymerase chain reaction array of 65 genes at the tumor suppressor locus 9q34.1‐2: Identification of 5 candidates tumor suppressor genes
Author(s) -
Amira Najla,
CancelTassin Géraldine,
Bernardini Stéphane,
CochandPriollet Béatrix,
Bittard Hugues,
Mangin Philippe,
Fournier Georges,
Latil Alain,
Cussenot Olivier
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20283
Subject(s) - urothelium , carcinogenesis , biology , tumor suppressor gene , cancer research , bladder cancer , gene , suppressor , transitional cell carcinoma , downregulation and upregulation , reverse transcription polymerase chain reaction , microbiology and biotechnology , gene expression , cancer , genetics , urinary system , endocrinology
Frequent deletions on 9q34.1‐2 were reported in bladder transitional cell carcinoma. High deletion mapping studies delimited a critical interval between markers D9S61 and D9S66, which is highly susceptible to contain a tumor suppressor gene. Expression level of the 65 genes localized in this region was analyzed by real‐time quantitative RT‐PCR, comparing tumor to normal urothelium. Five genes exhibited a significantly reduced expression level: C9orf9, KIAA0625, ABL1, LAMC3 and KIAA1857‐netrin‐G2, which exhibited the most significant downregulation ( p =0.0007). KIAA1857‐netrin‐G2 belongs to the netrins and might then be a tumor suppressor gene in bladder cancer, as netrin1 receptor DCC has been implicated in tumorigenesis. © 2004 Wiley‐Liss, Inc.
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