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Association of cigarette smoking with the risk of ovarian cancer
Author(s) -
Pan Sai Yi,
Ugnat AnneMarie,
Mao Yang,
Wen Shi Wu,
Johnson Kenneth C.
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20242
Subject(s) - medicine , odds ratio , confidence interval , ovarian cancer , case control study , population , gynecology , cancer , gastroenterology , environmental health
Cigarette smoking may be associated with ovarian cancer risk. This association may differ by histological type. The authors conducted a population‐based case‐control study in Canada of 442 incident cases of ovarian cancer and 2,135 controls 20–76 years of age during 1994–1997 to examine this association, overall and by histological type. Compared to women who never smoked, those who smoked had higher odds (odds ratio [OR] = 1.22; 95% confidence interval [CI] = 0.98–1.53) of having ovarian cancer, and the OR was larger for ex‐smokers (1.30; 95% CI = 1.01–1.67) than for current smokers (1.10; 95% CI = 0.81–1.49). The association with cigarette smoking was stronger for mucinous tumors (OR = 1.77; 95% CI = 1.06–2.96) than for nonmucinous tumors (OR = 1.13; 95% CI = 0.89–1.44). In addition, the odds of smokers having mucinous tumors increased with years of smoking (OR = 1.36, 1.88, 1.19, 4.89 for <20, 21–30, 31–40 and >40 years, respectively; p for trend = 0.002), number of cigarettes smoked per day (OR = 1.55, 1.89, 2.28 for <10, 11–20 and >20 cigarettes/day, respectively; p for trend = 0.014) and smoking pack‐years (OR = 1.13, 2.65, 1.77 and 2.39 for <10, 11–20, 21–30 and >30 pack‐years, respectively; p for trend = 0.004). Our data suggest that cigarette smoking is associated with an increased risk of ovarian cancer, especially for mucinous types. © 2004 Wiley‐Liss, Inc.