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Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
Author(s) -
Smits Kim M.,
Benhamou Simone,
Garte Seymour,
Weijenberg Matty P.,
Alamanos Yannis,
Ambrosone Christine,
Autrup Herman,
Autrup Judith L.,
Baranova Helena,
Bathum Lisa,
Boffetta Paolo,
Bouchardy C.,
Brockmoller Jurgen,
Butkiewicz Dorota,
Cascorbi Ingolf,
Clapper Margie L.,
Coutelle Christiane,
Daly Ann K.,
Muzi Giacomo,
Dolzan Vita,
Duzhak Tatyana G.,
Farker Katrin,
Golka Klaus,
Haugen Aage,
Hein David W.,
Hildesheim Allan,
Hirvonen Ari,
Hsieh Ling L.,
IngelmanSundberg Magnus,
Kalina Ivan,
Kang Daehee,
Katoh Takahiko,
Kihara Masahiro,
OnoKihara Masako,
Kim Heon,
Kiyohara Chikako,
Kremers Pierre,
Lazarus Philip,
Le Marchand Loic,
Lechner Maria C.,
London Stephanie,
Manni Johannes J.,
Maugard Christine M.,
Morgan Gareth J.,
Morita Shunji,
NazarStewart Valle,
Kristensen Vessela Nedelcheva,
Oda Yoshio,
Parl Fritz F.,
Peters Wilbert H.M.,
Rannug Agneta,
Rebbeck Timothy,
Pinto Luis F. Ribeiro,
Risch Angela,
Romkes Marjorie,
Šalagovic Jan,
Schoket Bernadette,
Seidegard Janeric,
Shields Peter G.,
Sim Edith,
Sinnett Daniel,
Strange Richard C.,
Stucker Isabelle,
Sugimura Haruhiko,
ToFigueras Jordi,
Vineis Paolo,
Yu Mimi C.,
Zheng Wei,
Pedotti Paola,
Taioli Emanuela
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20114
Subject(s) - gene , genetics , gstp1 , biology , carcinogen , tobacco smoke , genetic association , genetic predisposition , single nucleotide polymorphism , medicine , genotype , environmental health
Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case‐control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected ( n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1 , GSTM1 , GSTT1 , NAT2 and GSTP1 . None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected. © 2004 Wiley‐Liss, Inc.