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Smoking and the risk of breast cancer among carriers of BRCA mutations
Author(s) -
Ghadirian Parviz,
Lubinski Jan,
Lynch Henry,
Neuhausen Susan L.,
Weber Barbara,
Isaacs Claudine,
Baruch RuthGershoni,
Randall Susan,
Ainsworth Peter,
Freidman Eitan,
Horsman Douglas,
Tonin Patricia,
Foulkes William D.,
Tung Nadine,
Sun Ping,
Narod Steven A.
Publication year - 2004
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.20106
Subject(s) - medicine , breast cancer , menarche , oncology , risk factor , brca mutation , cancer , gynecology , case control study , obstetrics
The effect of cigarette smoking on the risk of breast cancer is controversial, although most studies show little or no effect. It has been suggested that smoking may reduce the risk of developing hereditary breast cancer. We completed a case‐control study on 1,097 women with breast cancer who were BRCA1 or BRCA2 mutation carriers and 1,097 age‐matched controls with a mutation in the same gene but without breast cancer. There were no statistically significant differences between the cases and controls in terms of the number of current and ex‐smokers (41.2% and 40.4%, respectively) or the age at smoking commencement (18.2 years and 18.5 years, respectively). There were no statistically significant differences between cases and controls regarding beginning smoking within 5 years of menarche (OR = 1.03; 95% CI 0.83 to l.28) or before the first pregnancy (OR = 1.09; 95% CI = 0.90 to 1.33). In conclusion, contrary to our previous report, smoking does not appear to be a risk factor for breast cancer among carriers of BRCA mutations. © 2004 Wiley‐Liss, Inc.